Muscle Contractions: How Neurotransmitters And Chemical Reactions Move Muscles And Bones

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Quadriceps femoris muscle

When the muscles of the quadriceps femoris group contract, they extend the knee joint, straightening the leg.

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An explanation of the muscular system and motion

How do the bones of the human skeleton move? Skeletal muscles contract and relax to mechanically move the body. Messages from the nervous system cause these muscle contractions. The whole process is called the mechanism of muscle contraction and it can be summarized in three steps:

(1) A message travels from the nervous system to the muscular system, triggering chemical reactions.

(2) The chemical reactions lead to the muscle fibers reorganizing themselves in a way that shortens the muscle--that’s the contraction.

(3) When the nervous system signal is no longer present, the chemical process reverses, and the muscle fibers rearrange again and the muscle relaxes.

Let’s look a little more closely at the steps in the mechanism of muscle contraction.

1. A Muscle Contraction Is Triggered When an Action Potential Travels Along the Nerves to the Muscles

Muscle innervation process

Muscle contraction begins when the nervous system generates a signal. The signal, an impulse called an action potential, travels through a type of nerve cell called a motor neuron. The neuromuscular junction is the name of the place where the motor neuron reaches a muscle cell. Skeletal muscle tissue is composed of cells called muscle fibers. When the nervous system signal reaches the neuromuscular junction a chemical message is released by the motor neuron. The chemical message, a neurotransmitter called acetylcholine, binds to receptors on the outside of the muscle fiber. That starts a chemical reaction within the muscle.

2. Acetylcholine Is Released and Binds to Receptors on the Muscle Membrane

Contracted state of sarcomere

A multistep molecular process within the muscle fiber begins when acetylcholine binds to receptors on the muscle fiber membrane. The proteins inside muscle fibers are organized into long chains that can interact with each other, reorganizing to shorten and relax. When acetylcholine reaches receptors on the membranes of muscle fibers, membrane channels open and the process that contracts a relaxed muscle fibers begins:

  • Open channels allow an influx of sodium ions into the cytoplasm of the muscle fiber.
  • The sodium influx also sends a message within the muscle fiber to trigger the release of stored calcium ions.
  • The calcium ions diffuse into the muscle fiber.
  • The relationship between the chains of proteins within the muscle cells changes, leading to the contraction.

3. Muscle Fibers Relax When the Nervous System Signal Is No Longer Present

Relaxed state of actin and myosin filaments

When the stimulation of the motor neuron providing the impulse to the muscle fibers stops, the chemical reaction that causes the rearrangement of the muscle fibers' proteins is stopped. This reverses the chemical processes in the muscle fibers and the muscle relaxes.

External Sources

A video by Armando Hasudungan on YouTube detailing the structure of skeletal muscle.

The Sliding Filament Theory of Muscle Contraction” by Jacob L. Krans, Ph.D. on Scitable.

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