Four Ways to Teach DNA Structure with Visible Biology

DNA can be hard to understand because it’s difficult to visualize, but it’s important for students to understand the structure of DNA  so they have a foundation to learn more complex concepts. 

Never fear, Visible Biology is here!

You might have heard about how Visible Biology can liven up your classroom and how learning in 3D can help students become more engaged and retain more information. Today on the blog, we’ll dive into four ways you can use Visible Biology to teach DNA structure. 

1. Be a DNA Tour Guide

You can use Visible Biology’s Tours feature to show students the internal structure of DNA and how DNA is stored in chromosomes. Learning about DNA is tied to learning about its shapes and how they fit into each other, so it’s helpful for students to be able to visualize this in 3D instead of relying on static images.

Before class, pull up the models and save the views you would like to use in your lecture, then create a Tour using these views.

Here is the URL to a sample tour to show your students an overview of DNA structure. It’s made up of six views that allow you to zoom in on different structures. To access the tour, click on the "Share Link" icon on the bottom right of your Visible Biology app and paste in the URL. Once you've accessed the tour, you can save it to your library by clicking "Save View" and then "Save Tour." 

View 1: Sugar backbone and base pairs. Start with the DNA strand, explaining to students that DNA is made up of two strands that twist into the iconic double helix shape. Point out the base pairs in the center of the structure. Explain that hundreds of thousands to millions of these base pairs make up a single molecule of DNA. 

View 2: Double helix. In eukaryotic cells, the double helix of DNA coils tightly and wraps around histone proteins. Play the animated model and as you move it around, explain that DNA wraps two and a half times around a cluster of eight histone proteins to make a nucleosome. 

View 3: Nucleosome coiling. Pause the animation and ask students to identify the structures they just saw in the previous animations. They should identify the nucleosome, made up of histones and DNA. 

View 4: Supercoiling. Illustrate how the coil made by the nucleosomes, connected like beads on a string, coils up again. Ask students why coiling is beneficial. 

View 5: Chromatin. Manipulate the model to show how coiling means there’s much more information in a smaller space. Show them the scale of the DNA base pairs versus the chromosome as a whole.

tour-view
Tours GIF from Visible Biology.

View 6: Parts of the chromosome. Walk students through the different parts of the chromosome: the Q arm and P arm joined together by the centromere with telomeres on the ends. 

By the end of this lecture, students will not only have an overview of the structure of DNA—they will have a deeper understanding of its spatial context. 

2. Design Scavenger Hunts

To show students the differences between prokaryotic and eukaryotic chromosomes, have them navigate the prokaryotic and eukaryotic models independently. Ask students to create Venn diagrams that list the similarities and differences between the models. 

When students are done, go through the differences and similarities between the two, highlighting what students might have missed from a quick look-over. Have them check off the ones they got correct and add in the points they did not write down. 

Students might notice that the eukaryotic DNA coils into chromatin and eventually makes up a chromosome. Point out that eukaryotic cells tend to hold more DNA than prokaryotic cells and that chromatin is made up of DNA and histones and is contained within the nucleus. The DNA and histones coil into nucleosomes, the nucleosomes coil into solenoid fibers, and solenoid fibers coil again when mitosis occurs. 

Students might notice that prokaryotic cells have a single, circular piece of DNA—prokaryotic cells have less DNA and do not use histones to coil DNA. Instead, DNA is supercoiled and compacted by nucleoid-associated proteins. Genetic material is located in the nucleoid, a region in the cell that, unlike the nucleus of a eukaryotic cell, is not surrounded by a membrane.

prokaryotic-dna-gif
Prokaryotic DNA GIF from Visible Biology

Here’s a handy table from the Visible Body Learn Site:

 

Eukaryotic Chromosome

Prokaryotic Chromosome

Shape

Linear

Circular

Size

Large

Small

Number

Multiple

Single

Location

Nucleus

Nucleoid (region in cytoplasm)

Storage proteins

Histones

Nucleoid-associated proteins

 

Explain that these differences mean that when it comes time for DNA replication before cell division, there are some small variations in the process. These differences in process usually pertain to the size and complexity of the DNA. 

Students will learn about these differences through tactile learning as they manipulate the models, and they will walk away with notes to study from. 

 

3. Make a Flashcard Game Show

Flashcards are a popular study tool because they encourage students to actively retrieve information instead of just rereading their notes—but they can also be used to gamify your classroom! 

Gamification refers to the process of, well, making a game out of classroom activities. If you’ve ever reviewed vocabulary with a game of bingo or quizzed students using Kahoot!, you’ve gamified your class. Games can be a great way to energize students and encourage collaboration, so here’s an example of how it can be incorporated using Flashcards. 

First, students should have an understanding of the molecular structure of DNA. Through lecture or textbook reading, they should understand:

  • DNA is made up of units called nucleotides, which are made of a sugar molecule (deoxyribose), a phosphate group, and a nitrogenous base. 
  • The sugar of one molecule joins with the phosphate group of another molecule through covalent bonding, forming the sugar-phosphate backbone. 
  • The rungs of the DNA ladder are nitrogenous bases: cytosine, guanine, adenine, and thymine. Adenine pairs with thymine and cytosine pairs with guanine.
  • The order and number of the base pairs code for specific proteins—these sequences are genes. 

For this game, you can easily make your own Flashcard deck and write prompts using the text feature, or you can use our pre-made biology Flashcard decks, which ask students to identify different structures. 

base-pair-flashcard
Flashcard GIF from Visible Biology.

Project the Flashcard deck so that all students can see clearly, and split your class into teams of 3-5. Ask each team to choose a leader to write down their answers on a small whiteboard or a piece of paper. 

Show students the first side of the Flashcard and give them time to consult their notes, discuss, and form their answer. After they have written down their team’s answer, the leader should “buzz in” by raising their hand.

When all groups have answered the question, flip the flashcard by clicking on it and award points—a bonus point is awarded to the first group to get the answer correct.

This game can be used as a review to ensure students understand new concepts or as a refresher before moving on to other content. All Flashcard decks can be shared with a few easy clicks, so students can use the same decks at home as study materials. 

 

4. Reinforce Lessons with Video

Did you know that Visible Biology has a YouTube series where Dr. Cindy Harley of Metropolitan State University unpacks biology content to help viewers tackle tricky concepts? This series includes visuals from the Visible Biology models students work with in the classroom, so when students use it to review information, it reinforces knowledge on a visual level as well.

You can use the flipped classroom model by having students view Lesson 1: The Structure of DNA as a homework assignment. This frees you up to answer questions and give students individual attention during class time.

 

In the classroom, send your students on a scavenger hunt on their laptops, phones, or tablets to find the structures Dr. Harley mentioned in the video. 

Some ideas for scavenger hunt prompts:

  • Find the sugar-phosphate backbone
  • Find the three ingredients that make a nucleotide
  • Find the nitrogenous bases that have one ring
  • Find the base that binds with guanine 

Ask your students to save their answers as saved views so they can check their work. 

Here’s another way to use the Visible Biology YouTube series in your classroom: kick off a conversation about science history with Lesson 4: The Discovery of DNA’s Structure. 


Here are three discussion questions to get students thinking: 

  • How did the outbreak of Spanish Flu in the 1920s influence the discovery of DNA structure?
  • What’s the importance of Photo 51 (shown at 7:27)?
  • Why is the Nobel Prize so important? What does it mean to exclude Martha Chase and Rosalind Franklin?

Looking for more?

Looking for more ways to use Visible Biology in your classroom? Check out these resources:

For a free instructor trial of Visible Biology, contact our Education Team. Happy teaching!

 


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